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1/30/20

Peptides for Regeneration

This week, we would like to continue our peptide theme.

Those of you who have read through one of our customized Regenerative Treatment Plans undoubtedly noticed we use at least a couple of peptides as supplements to increase the success rate of our therapies.

So, what do these peptides do and why do we use them?

BPC-157 - Body Protection Compound 157

This is a biologically active sequence of 15 amino acids (which are the building blocks of proteins). It is isolated from gastric juice, and can be administered subcutaneously, intra-muscular, oral, or intra-nasal.

BPC 157 is an anti-inflammatory and promotes tissue healing. In animal studies, it was proven to repair muscle, tendon, bone, teeth, cornea, brain, and intestine. It is thought to achieve these effects through activation of growth hormone receptors.

In our Regenerative Therapies, we are particularly interested in helping tendon and ligaments heal, and BPC 157 was proven to promote these processes through decreasing inflammation, regeneration, and remodeling. It promotes collagen organization, which is exactly what the growth factors in platelet-rich plasma and stem cells also effect.

In addition to its effectiveness in musculoskeletal healing, BPC 157 was also proven to heal the lining of the bowel if previously damaged by gastro-esophageal reflux disease (GERD), NSAID use, etc. Trials of BPC 157 in inflammatory bowel disease have also shown promise.

BPC 157 works also on the gut-brain axis, is neuroprotective and promotes nerve regeneration.

CJC 125 with ipamorelin

We use the combination of these two peptides to promote release of growth hormone in the most natural way possible.

CJC 125 is a peptide that activates the pituitary gland receptor for Growth Hormone Releasing Hormone (GHRH). GHRH is a hormone secreted by the brain that normally acts on the pituitary to promote the release growth hormone. CJC 125 is an analog of the GHRH.

Ipamorelin acts on a different receptor in the pituitary to promote secretion of growth hormone, so it has a synergistic effect with CJC 125.

We believe that a transient elevation of growth hormone during our regenerative treatments is beneficial for regeneration, repair and growth.

Some of the factors that stimulate growth hormone secretion are

  • low blood glucose
  • fasting (which we also encourage)
  • decreased blood fats
  • trauma, stress, excitement
  • exercise (another important factor in our program)
  • testosterone, DHEA (in women) and estrogen (which is why we encourage our patient to check their biomarkers and optimize them)
  • deep sleep (stages II and IV)
  • Growth hormone releasing hormone (and its analog CJC 125)
  • growth hormone secretagogues (like ipamorelin)

We hope this post explains a little bit more our protocols. We put a lot of thinking in each protocol we offer, and we tailor them to each individual patient. This is what we call “N=1 Medicine”, or Precision Medicine. The success of our therapies hinges on many factors. We hope that our recent series of blogs have shed some light on some of these factors.

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